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PhD candidate 3D-Marfan Smooth Muscle Morphology

Apply before: 21 January 2019
Type of Employment: Fixed Term Contract
Working hours: 36 hours per week
Discipline: AMC Medical Research (AMR)
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What you are going to do

We have a vacancy for a talented and enthusiastic PhD candidate to join our team at the Amsterdam UMC, location AMC.

Marfan Syndrome patients have a mutation in fibrillin-1 (FBN1), leading to skeletal, ocular and severe cardiovascular problems. One of these cardiovascular problems is widening of the aorta (aneurysm) with aortic rupture as main risk factor with often fatal consequences. These aortic problems may already occur at a very young age and patients usually die before the age of 40 if they are not operated for aortic replacement in time. We aim to prevent or postpone aortic surgery by identification of pharmacologic treatment strategies. However, over 2000 different mutations have been described in the FBN1 gene causing Marfan Syndrome. So far, we identified two categories of Marfan patients, based on the type of mutation, explaining disease severity and drug sensitivity. In the current project the PhD candidate will collaborate with the 3D-cell culture/imaging company OcellO. Vascular smooth muscle cell 3D-culture assays will be developed to understand the impact of different FBN1-mutations on smooth muscle cell morphology and intracellular signaling pathways. We aim to stratify patients based on these characteristics and predict their drug sensitivity. This study also involves close collaboration with the physicians treating Marfan patients.

 What we expect from you

A recent MSc in Medical/Molecular Biology or related discipline, preferably with a background in molecular cell biology and pathology. We expect a team player with a drive for science, highly motivated to become an independent researcher.

Where you are going to work

The PhD candidate will work in the group of Dr. de Waard at the department of Medical Biochemistry in the AMC. He/she will work in a team of experienced staff, PhD candidates and technicians with excellent infrastructure. There will be intense collaboration with OcellO and the Marfan clinic (Cardiology/Genetics) at the Amsterdam UMC.

What we offer you

We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.

  • The maximum gross monthly salary based on a 36-hour work week is € 3.020,- (scale OIO CAO UMC).commensurate with qualifications and experience 
  • The base salary does not include holiday pay (8%) and a year-end bonus (8.3%). 
  • We offer a fulltime position for a period of 4 years
  • In addition to excellent accessibility by public transport, AMC also has a sufficient number of parking spaces for employees.
  • Pension is accrued at Be Frank.

For an overview of all our other terms of employment, see www.werkenbijamc.nl/arbeidsvoorwaarden-amr

Let’s meet

If you would like to apply directly, please use the ‘apply’ button on this page.
If you would like more information, please feel free to contact Dr. Vivian de Waard, via v.dewaard@amc.nl.

We look forward to meeting you!

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