We have a vacancy for a talented and enthusiastic PhD candidate to join our team at the Amsterdam UMC, location AMC.
Atherosclerosis is the underlying cause of cardiovascular diseases such as myocardial infarction. Macrophages play an important role in atherosclerosis and we demonstrated that the transcription factor Nur77 has an anti-inflammatory function in these cells. In this project, we will delineate the exact role of Nur77 in macrophages and identify small-molecule drugs to enhance its activity. Specific mutations will be introduced in Nur77 to interfere with DNA binding and dimerization, followed by functional analyses in cultured cell lines and primary mouse macrophages. CRISPR/Cas technology will be applied to generate mice with specific Nur77 mutations. Next, we will perform atherosclerosis experiments and test novel drugs. Our multidisciplinary approach involves state-of-the-art molecular biology, metabolomics, bioinformatics, cellular models and in vivo models. Eventually we aim to apply small-molecule drugs for therapeutic intervention in chronic inflammatory disease.
A recent MSc in Medical/Molecular Biology or related discipline, preferably with a background in molecular cell biology and interest/experience with animal experiments. We seek for a team player with a drive for science, highly motivated to become an independent researcher.
The PhD candidate will work in the De Vries-group at the department of Medical Biochemistry in the AMC. The department houses six different research groups with over 70 researchers among which 30 PhD candidates. He/she will work in a team of experienced staff and technicians with excellent infrastructure. The research of the department involves projects focusing on vascular biology, immunity and metabolism.
We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.
For an overview of all our other terms of employment, see www.werkenbijamc.nl/arbeidsvoorwaarden-amr
If you would like to apply directly, please use the ‘apply’ button on this page.
If you would like more information, please feel free to contact Prof. dr. Carlie de Vries ,via firstname.lastname@example.org.
We look forward to meeting you!