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PhD candidate Nur77 in Macrophages

Apply before: 21 January 2019
Type of Employment: Fixed Term Contract
Working hours: 36 hours per week
Discipline: AMC Medical Research (AMR)
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What you are going to do 

We have a vacancy for a talented and enthusiastic PhD candidate to join our team at the Amsterdam UMC, location AMC.

Atherosclerosis is the underlying cause of cardiovascular diseases such as myocardial infarction. Macrophages play an important role in atherosclerosis and we demonstrated that the transcription factor Nur77 has an anti-inflammatory function in these cells. In this project, we will delineate the exact role of Nur77 in macrophages and identify small-molecule drugs to enhance its activity. Specific mutations will be introduced in Nur77 to interfere with DNA binding and dimerization, followed by functional analyses in cultured cell lines and primary mouse macrophages. CRISPR/Cas technology will be applied to generate mice with specific Nur77 mutations. Next, we will perform atherosclerosis experiments and test novel drugs. Our multidisciplinary approach involves state-of-the-art molecular biology, metabolomics, bioinformatics, cellular models and in vivo models. Eventually we aim to apply small-molecule drugs for therapeutic intervention in chronic inflammatory disease.

What we expect from you 

A recent MSc in Medical/Molecular Biology or related discipline, preferably with a background in molecular cell biology and interest/experience with animal experiments. We seek for a team player with a drive for science, highly motivated to become an independent researcher.

Where you are going to work 

The PhD candidate will work in the De Vries-group at the department of Medical Biochemistry in the AMC. The department houses six different research groups with over 70 researchers among which 30 PhD candidates. He/she will work in a team of experienced staff and technicians with excellent infrastructure. The research of the department involves projects focusing on vascular biology, immunity and metabolism.

 

What we offer you 

We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.

  • The maximum gross monthly salary based on a 36-hour work week is € 3.020,- (scale OIO CAO UMC). commensurate with qualifications and experience 
  • The base salary does not include holiday pay (8%) and a year-end bonus (8.3%). 
  • We offer a fulltime position for a period of 4 years, starting with a year contract. 
  • In addition to excellent accessibility by public transport, AMC also has a sufficient number of parking spaces for employees.
  • Pension is accrued at Be Frank.

For an overview of all our other terms of employment, see www.werkenbijamc.nl/arbeidsvoorwaarden-amr

Let’s meet 

If you would like to apply directly, please use the ‘apply’ button on this page.
If you would like more information, please feel free to contact Prof. dr. Carlie de Vries ,via c.j.devries@amc.nl.

We look forward to meeting you!

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