Optical Coherence Tomography (OCT) is a medical imaging modality for 3D visualization of tissue at micrometer scale resolutions. Next to imaging, optical properties of the tissue can be derived which are related to the tissue’s physiological function (such as perfusion) and structural organization (which can be an indicator of e.g. cancer progression). The potential for OCT as a diagnostic aide has been recognized in various medical fields, ranging from opthalmology and cardiology to dermatology, urology and gastroentrology. However, application is currently constrained by physical factors such as instrument size and imaging geometry. The goal of this project is to remove these constraints by replacing the conventional bulk optics OCT system with a highly miniaturized instrument based on integrated photonics technologies. In recent years, our research group in collaboration with other partners have demonstrated that it is feasible to manufacture the various components (waveguides, splitters, arrayed waveguide gratings) in integrated photonic technology. In this project, we, together with TU Eindhoven and 6 companies, will realize and demonstrate a miniaturized imaging system that uses 1300nm and 1550nm wavelength ranges to enable diagnostic quantitative imaging of biological tissue. To achieve this two types of photonic integrated circuits will be combined. New semiconductor photonic integration technology operating at 1300nm and new innovative tunable laser systems will be developed and investigated. With these combined wavelength ranges, you will explore the possibilities to obtain functional information of living tissues.
You have a recent Msc in physics or (biomedical)b engineering (or equivalent). You have affinity for applying optical technology to medical applications. Skills from the optics or electronics lab are considered a pre. Programming skills, specifically for controlling instrumentation, data (image) acquisition and processing are required, preferably in LabVIEW or Matlab. You are motivated to become an independent researcher. You are a team player that can communicate and work efficiently with the various project partners.
The Biomedical photonics group within the Biomedical Engineering & Physics department of Amsterdam UMC, location AMC (BMEP), headed by prof. Van Leeuwen, investigates the interaction of light with tissue in order to obtain quantitative functional information. Thereto, various medical devices and dedicated signal analysis have been developed for and evaluated in the clinic, e.g. cardiology and urology. For OCT specifically, the correlation of OCT signal with intrinsic physical and optical properties of (living) tissue has been studied for over 15 years. This group is leading on designing and building OCT setups for clinical applications, the physical interpretation of data obtained using OCT (such as measurements on blood flow) as well as of clinical application of OCT using miniaturized devices. Currently the biomedical photonics group contains 5 staff members, 4 postdocs and 25 PhD students.
We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.
For an overview of all our other terms of employment, see www.werkenbijamc.nl/arbeidsvoorwaarden-amr
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