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PhD position in Amsterdam in functional genetics of lipid metabolism

Apply before: 6 March 2020
Working time: Day
Working hours: 36 hours per week
Discipline: AMC Medical Research (AMR)

What you are going to do

Lipid metabolism is tightly regulated both at the cellular as well as whole-organism level. This regulation ensures that the level of lipids does not increase to toxic levels and that they are available at sufficient amounts for processes requiring them. Disruption of this balance is at the center of several pathological conditions in humans, most notably fatty liver and cardiovascular disease.

Our group is broadly interested in the transcriptional and post-transcriptional regulation of lipid and energy metabolism. We recently applied genome-wide functional genetic screens to identify novel genes that play a role  in these processes (Loregger et al. ATVB 2017; Tan et al. Atherosclerosis 2019, Loregger et al. Nat. Comm, in press). In this VICI-supported project we will apply CRISPR/Cas9- or haploid-based genome-wide functional genetic approaches to study lipid-associated cellular processes including, amongst others, cholesterol and fatty acid synthesis and intracellular sterol trafficking. The goal of this project is to identify novel genes and elucidate the molecular mechanisms that govern these processes, and investigate whether these play a role in cardiovascular and metabolic disease. A wide range of advanced techniques will be used in this project, including state-of-the-art genetic screens, cell-based functional assays, metabolomics, mass spectrometry, and molecular biology.

What we expect from you

We are looking for a broadly-trained and highly-motivated PhD candidate with an MSc in Medical Biology, Life Sciences, Biochemistry or a related field. Experience and/or affinity with functional genetic screens, next-generation sequencing, or bioinformatics is an advantage. The candidate should have good command of oral and written English. Excellent communication skills and the ability to work within an international research group are essential. The appointment will be for 4 years.

Where you are going to work

The Zelcer group is located in the Department of Medical Biochemistry. Information on our research and group can be found on our website: http://www.zelcerlab.eu/.

What we offer you 

We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.

  • The maximum gross monthly salary based on a 36-hour work week is € 3.103,- (scale OIO CAO UMC).
  • The base salary does not include holiday pay (8%) and a year-end bonus (8.3%).
  • We offer a contract for 4 years.
  • In addition to excellent accessibility by public transport, AMC also has a sufficient number of parking spaces for employees.
  • Pension is accrued at Be Frank.

 For an overview of all our other terms of employment, see https://werkenbijamc.nl/arbeidsvoorwaarden-amr/.

Let’s meet 

If you would like to apply directly, please use the ‘apply’ button on this page.
If you would like more information, please feel free to contact Prof. Dr. Noam Zelcer, via n.zelcer@amsterdamumc.nl.

Applications should include a CV, cover letter, and the contact information of three references. An assessment may be part of the selection procedure.

We look forward to meeting you!