The Pediatric Surgery department (Emma children’s hospital Amsterdam) and the Tytgat Institute, Amsterdam UMC has an opening for a PhD research fellow within the Gut Research Group, on an NWO funded VIDI program on the pathophysiology of intestinal anastomotic leakage (J. Derikx, 2020-2024). This program is aimed to expand on new pathological insights, biomarker diagnostics and fundamental knowledge on the role of neuronal innervation in the intestinal crypt. The intestinal crypt is innervated by adrenergic extrinsic neurons. This innervation is functional as we have pilot data showing that intestinal organoids are highly responsive to neurotransmitter agonists, and Crispr editing shows functional roles for neuronal innervation in intestinal crypt proliferation. Here, we aim to test whether neuronal activity affects intestinal anastomotic healing in human organoids, clinical tissues, and a mouse model. In the NWO project program, of which this project is a part, we wish to study this process in detail and design applications for intervention in human. The emergence of high-throughput technologies and the societal need for evidence-based interventions that fortify a healthy recovery from surgery have spurred academic and industrial interest in the development of precision medicine for immune homeostasis and recovery post-surgery. These trends call for basic science but also business-oriented researchers who can think of innovative ways to address challenges in this field.In addition to undertaking a doctoral research degree, the PhD students will engage through the Amsterdam UMC graduate school in a series of collaborative training events to develop advanced skills and expertise in tackling challenges linked to intestinal physiology, next gen sequencing, microbiome research and more. This project is strongly related to clinical expertise and activity, as well as translational and fundamental lab facilities at Amsterdam UMC. Your supervisory team will consist of dr Joep Derikx (PI of the VIDI study) and prof dr Wouter de Jonge (chair in Exp Gastroenterology at Amsterdam UMC). You will be embedded and facilitated through the 24FTE Gut Research science group, located at Amsterdam UMC premises.
REQUIRED EDUCATION LEVEL
A degree (MSc, or equivalent) in Health and/or Life Sciences (Biology, Medicine, Microbiology, Molecular Biology, Immunology, Biomedical Sciences, Biochemistry or closely related fields) or Medicine (Surgery, Paediatrics or Internal Medicine). Candidates in the final stages of obtaining their degree are invited to apply.
We expect a Master´s degree (or equivalent) in Health and Life Sciences, Data Sciences or Medicine. Furthermore, the applicant should be able to perform team-oriented as well as independent work. Desirable methodological skills: excellent background in molecular biology, biochemistry, cell biology, immunology and/or microbiology, hands-on knowledge of analytical methods.
The Amsterdam University Medical Centre (AUMC) is one of the foremost research institutions in the Netherlands, as well as one of its largest hospitals. Over 7,000 people work here to provide integrated patient care, fundamental and clinical scientific research, and teaching. The department of Paediatric Surgery and the Tytgat Institute for Liver and Intestinal Research of AMC participate in this research. The highly translational research performed in collaboration between these departments is particularly focused on the pathophysiology of intestinal ischemia-reperfusion, intestinal anastomotic leakage and intestinal maturation (including the derailment of the inflammatory response leading to necrotizing enterocolitis). Dr Joep Derikx (Paediatric Surgery) and Prof. Wouter de Jonge (Tytgat Institute) will be supervising the ESR project at AUMC.
We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.
For an overview of all our other terms of employment, see https://werkenbijamc.nl/arbeidsvoorwaarden-amr/
If you would like to apply directly, please use the ‘apply’ button on this page.
If you would like more information, please feel free to contact Joep Derikx (Kinderchirurg), via firstname.lastname@example.org.
We look forward to meeting you!
Because of the coronavirus, healthcare is our main focus now in Amsterdam UMC. This means that it will probably take longer before we give you feedback on your application, or schedule job interviews. Thank you for your understanding!