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PhD position: PEV3 infection & determinants of susceptibility

Apply before: 1 April 2019
Type of Employment: Fixed Term Contract
Working hours: 36 hours per week

What you are going to do

This research project focuses on researching the determinants of susceptibility regarding the PEV3 infection. During this project, you will be focussing on the following research objectives:

  • Identify the role of viral genotype and donor age in determining susceptibility of human gut to infection with PEV3
  • Identify which cells are infected by PEV3 in human gut & respiratory tissue
  • Establish the known role of PEV3 receptors in infecting human gut & respiratory tissues

With this project, we aim to achieve the following results:

  • Establishment of the HAE PEV3 infection
  • Establishment of human infection models to study pathogenesis of PEV3
  • Identification of viral factors (mutations) and host factors (age, tissue, receptor expression) that affect susceptibility of host cells to infection with PEV3

This project also includes two secondments, which are as follows:

  • A two-month secondment with Charles River (location: Leiden, the Netherlands) focused on bringing gut organoids from the Amsterdam UMC to Charles River.
  • A three-month secondment with the University of Jagielloński (location: Krakow, Poland) focused on learning about advanced cell staining and receptor identification.

You will be guided during your research project by Katja Wolthers (Department of Medical Microbiology) and Dasja Pajkrt (Paediatric Infectious Disease Specialist).
This research project is provided by Organovir, an Innovative Training Network (ITN) that focuses on the implications of organoid technology for viral pathogenesis studies and anti-viral testing. Organovir has an international consortium that exists out of 10 beneficiaries and 5 partners from various sectors, such as academics, industry as well as the governmental and non-profit sector. One of these beneficiaries is the Amsterdam UMC.

As a researcher with Organovir, you will be able to familiarize yourself not only with the scientific and technical aspects of innovative 3D culture systems for virus research, but also with the financial, commercial, ethical, communicative, policy and dissemination aspects enabling optimal valorisation of organoids. At the end of this project, you will hold a unique position within the European labour market.

What we expect from you

For this research project we are looking for a young researcher who is highly motivated and enthusiastic with a flexible, pro-active team spirit and a recent Master degree in the field of biochemistry, cell biology, molecular biology, virology, tissue engineering, pharmaceutical sciences or life sciences/medicine. Interest and experience in virus culture and organoid technology is an advantage. The candidate is required to be proficient in the English language and should be in the first four years (full-time equivalent) of their research careers. In addition, the applicant should not, at the time that he/she is selected by the host institution, have resided or carried out their work and/or studies in the country of the host institution for more than 12 months in the 3 years immediately prior to their recruitment. Find here an overview of the requirements.

Are you a Dutch Candidate and are you interested in pursuing your PhD abroad? Then check Organovir’s international vacancies on their website.

Where you are going to work

The Department of Medical Microbiology.

What we offer you

We offer a 4-year research position for 36 hours per week within a motivated and innovative consortium. The salary is in accordance with CAO-UMC, scale 21. In addition, we offer a holiday allowance of 8% of the gross annual salary. The starting date of the research project is the 1st of September 2019.

Let’s meet

Do you want to be trained as an expert in innovative organoid technology? Are you open-minded, curious, ready to explore new ways, and do you like the challenge of working in a dynamic international network with 15 PhDs at academic, commercial and public health institutes, covering different aspects of innovative organoid technology?

Then we want to hear from you!

Visit the Organovir website and fill in the application form. The deadline for applications is the 1st of April, 2019. Only complete applications will be considered.
Do you have a question or do you need more information? Then send an email to info@organovir.com.