Atherosclerosis, the main pathogenesis of cardiovascular disease is a lipid- driven inflammatory disease. Inflammation of the endothelium plays an important role in this process and recently it has been shown that alterations in their intracellular metabolism is interictally linked to their inflammatory phenotype, facilitating atherogenesis. In this project, we aim to investigate the role of endothelial cell metabolism in driving cardiovascular disease, in order to gain new insight in the crosstalk between this metabolism-driven inflammatory response of the endothelium under hyperlipidemic conditions. To do so, you will use both in-vitro (including metabolomics, qPCR analysis and RNA-sequencing, Seahorse Flux analysis, Immunoblotting, ELISAs) as well as work with animal (mouse) models. Together with the department of Vascular Medicine, we will validate our findings in human cohorts.
We are looking for a highly motivated and enthusiastic PhD student with a strong interest in vascular cell biology. You have a master degree in a relevant study and received excellent scientific training in the field of cell biology, vascular biology or a related field. You have a strong affinity cellular (imaging) techniques, with animal (mouse) work, you are article 9 certified (completed the course Laboratory Animal Science “proefdierkunde”). You have outstanding experimental research skills, are a team-player, well-organized and results-driven. You furthermore have good written and spoken English language skills.
The candidate will work at the department of Experimental Vascular Medicine, a department that is closely intertwined with the department of Vascular Medicine. You will work in a dynamic and ambitious team of PhD students, technicians, clinicians and bio-informaticians with excellent infrastructure. The department is specialized in performing multidisciplinary research that ranges from bench-to-bedside. The group that the candidate will be working in is a new, young and motivated research group that actively working with both clinical and fundamental research groups within our departments as well as on a (inter)national level.
We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.
For an overview of all our other terms of employment, see https://werkenbijamc.nl/arbeidsvoorwaarden-amr/
If you would like to apply directly, please use the ‘apply’ button on this page.
If you would like more information, please feel free to contact Jeffrey Kroon (Assistant Professor), via 020 – 56 61150 or email@example.com.
We look forward to meeting you!