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PhD student Genetics of Cardiac Conduction and arrhythmia

Apply before: 31 August 2020
Working time: Day
Working hours: 36 hours per week
Discipline: AMC Medical Research (AMR)

What you are going to do

We are looking for talented people to join our research group! Keywords: cardiac arrhythmias, genetics, molecular biology, electrophysiology, enthusiastic, ambitious, team work.
If you want to perform cutting edge research to help improve the burden of cardiovascular disease and are a talented researcher with a (bio)medical background and a keen interest in human genetics we may be looking for you!

We have a vacancy for a PhD student to join our team at the Academic Medical Center in Amsterdam. Our diverse and ambitious team conducts multidisciplinary and translational research, spanning clinical cardiology, clinical genetics, molecular biology, biostatistics and disease modelling in cellular systems and mice.
The successful applicant will work to unravel the molecular mechanisms underlying cardiac conduction disease and supra-ventricular arrhythmias. While the genetics of ventricular arrhythmias has been extensively studied, our knowledge of supra-ventricular arrhythmias lags behind. The recent description of the role of TNNI3K in supraventricular arrhythmias by me and others is a useful step forwards, however the underlying mechanisms remain unsolved. To further understand the full impact of these mutations on conduction in human the development of a more specific human induced pluripotent stem cell (IPSC) derived model is required. Furthermore, multiple families with supraventricular arrhythmias and or early onset atrial fibrillation have been collected. These families, thus far genetically unsolved, are likely amenable to modern genetic techniques: whole genome sequencing, locus mapping, genetic burden testing. This project will address these questions.
The PhD student will focus on human genetics: identification of genetic variants and novel genes associated with human cardiac disease. You will perform (molecular and electrophysiological) impact assessment in cell systems including human induced pluripotent stem cell derived cardiomyocytes.

This project is funded by NWO (VIDI), the Dutch Heart Foundation and the Academic Medical Center. The successful applicant will be expected to develop novel ideas and assays, investigate the clinical phenotype of affected individuals in collaboration with the treating physicians, perform genetic studies, and in collaboration with the rest of the team perform functional assays.

What we expect from you

We are looking for a talented PhD candidate with the ability to perform a bridging role between the clinic and the laboratory. A keen interest in human genetics and in the impact of basic science on (future) treatment of cardiac disease is the most important prerequisite for this function.You have an MSc degree in Medicine or Medical Biology 

  • You have a strong interest in human genetics and cardiac disease
  • You are flexible and can handle different projects concurrently
  • You are a team player that shares knowledge and skills with colleagues
  • You are independent and have good organizational skills
  • You have excellent written and verbal communication skills
  • You are fluent in English (written and spoken)
  • You are fluent in Dutch (necessary for the interpretation of medical files)
  • You have (or are eligible for) a work permit in the Netherlands/EU Schengen zone 

Where you are going to work

Amsterdam UMC, location AMC, is more than just a hospital. It is a world in which patient care, research and education are integrated, and in which people are always central. It is an academic world full of possibilities for talented individuals that are looking for a place where they can excel. Thinking big, daring to dream, cooperating internationally. And never letting yourself be put off by ‘It’s not possible’ or ’It won’t work anyway’. That is the Amsterdam UMC, location AMC, mentality.

This PhD project will be conducted in the department of Experimental Cardiology. This department is the research laboratory of the Heart Centre of the Amsterdam UMC, location AMC consisting of 5 groups each led by a group leader / principal investigator. The multidisciplinary nature of these groups and the long-standing tradition of research on cardiac arrhythmias that cause sudden cardiac death enables the strong scientific track record of the department. The department is an integral part of the ‘Hartcentrum’ of Amsterdam UMC, location AMC, which means that researchers are connected to the Clinical Cardiology department, which stimulates translational research that benefits patients suffering from life-threatening cardiac diseases.

What we offer you

We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.

  • A PhD student (Onderzoeker in Opleiding) is placed in scale 21, with a fulltime gross salary that ranges from €2495,- to €3196,- (based on qualifications and experience).
  • A Medical Doctor (Arts-Onderzoeker) it placed in scale 10, with a fulltime gross salary that ranges from €3196,- to €3788,- (based on qualifications and experience).
  • The base salary does not include holiday pay (8%) and a year-end bonus (8.3%).
  • We offer a contract for 12 months.
  • In addition to excellent accessibility by public transport, AMC also has a sufficient number of parking spaces for employees.
  • Pension is accrued at Be Frank.

For an overview of all our other terms of employment, see https://werkenbijamc.nl/arbeidsvoorwaarden-amr/

Let’s meet

If you would like to apply directly, please use the ‘apply’ button on this page.
If you would like more information, please feel free to contact Elisabeth Lodder, universitair docent, e.m.lodder@amsterdamumc.nl.

We look forward to meeting you!

A screening and/or medical examination may be part of the selection procedure. This requires access to DigiD.