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PhD student VICI project bile acid signalling to combat hepatosteatosis

Apply before: 5 May 2021
Working time: Day
Working hours: 36 hours per week
Discipline: AMC Medical Research (AMR)

What you are going to do

The Amsterdam University Medical Center (location AMC, Amsterdam) has a vacancy for a PhD student at the Tytgat Institute for Liver and intestinal Research. The aim of the project is to investigate whether inhibition of the bile acid transporter NTCP can be used to treat NAFLD/NASH. Furthermore, the project aims to understand bile acid signalling related to liver inflammation and fat accumulation in great detail. We use state-of-the-art molecular/cellular ex-vivo techniques combined with genetic models and diet-induced models for metabolic diseases and/or bile acid transport.

What we expect from you

We are looking for a highly talented PhD student with a Master’s degree in a field related to (medical) biology or biochemistry. You have a keen interest in understanding the molecular basis of hepatic (patho)physiology and its (future) implications for the clinic, article 9 or similar FELASA qualifications, and are proficient in English.

Where you are going to work

You will be contracted by AMC Medical Research, and work in a team based in the Tytgat institute for Liver and Intestinal Research. The liver and intestinal research of the AMC is concentrated in this department which is affiliated with the Department of Gastroenterology & Hepatology. Housing more than 70 basic and clinical scientists, we are one of the leading international research centers in gastroenterology and hepatology. Research in the Tytgat Institute is both fundamental and translational, but always built on a clinical question, providing results that can be translated into clinical practice. Extensive collaboration between physicians and researchers ensures a close link between the clinic and basic research. Daily supervision will be by Dr. Stan F.J. van de Graaf.

Want to know more about working at AMR? Take a look at our website https://werkenbijamc.nl/werken-bij-amr/.

What we offer you

We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.

  • The maximum gross monthly salary for a PHD candidate based on a 36-hour work week in the first year is € 2.495,- and increases up to the fourth year to € 3.196,- (scale OIO CAO UMC).
  • The base salary does not include holiday pay (8%) and a year-end bonus (8.3%). 
  • We initially offer a contract for 12 months with the prospect of extending the contract, upon good performance, up to 4 years in total.
  • The project will be performed at the Tytgat Institute for Liver and Intestinal Research, which is currently based at the Meibergdreef (location AMC).
  • In addition to excellent accessibility by public transport, AMC also has a sufficient number of parking spaces for employees.
  • Pension is accrued at Be Frank.

For an overview of all our other terms of employment, see https://werkenbijamc.nl/arbeidsvoorwaarden-amr/

Amsterdam UMC has an open culture. Together we continuously build an environment where everyone feels welcome. To achieve that, we strive to provide equal opportunities for everyone. We therefore cordially invite all interested parties to respond to this vacancy.

Let’s meet

If you would like to apply directly, please use the ‘apply’ button on this page.
If you would like more information, please feel free to contact Stan van de Graaf (Associate professor), via k.f.vandegraaf@amsterdamumc.nl.

Based on your CV and motivation letter Stan van de Graaf will select a number of candidates for a short introductory interview round. Most-suited candidates will be invited for a second, more extensive round, which includes an assessment, multiple interviews with group members and head of department. This allows the applicant to learn the project demands and to get to know the group/institute and us find the best match.

We look forward to meeting you!