The Post Doc position will be focused on sepsis related topics in the intensive care setting. Sepsis is defined as life-threatening organ dysfunction due to a dysregulated host response to infection. Mortality is high (15-40% at 28 days) and survivors frequently suffer from long-term sequelae. Extracellular histones have been identified as essential mediators in the pathogenesis of sepsis. These toxic molecules are released by damaged cells in response to infection and high extracellular levels can induce tissue injury and multiple organ dysfunction syndrome. Extracellular histones can be neutralized by complexation with a new non-anticoagulant heparin, allowing the use of elevated dose levels relative to regular unfractionated heparin. This new heparin has been tested for safety and efficacy in animal studies and is available as a cGMP manufactured formulation. The overall objective of the Histoseps project is to investigate the new drug as an add-on therapy for selected sepsis patients by conducting an exploratory phase I/IIa study. Furthermore, we will participate in the ImmunoSep trial a phase III study. The aim of the ImmunoSep study is to assess whether personalized adjunctive immunotherapy directed against a state of either fulminant hyper-inflammation or immunoparalysis is able to change the sepsis outcomes. The Post Doc will be responsible for running the trials including the coordination with the other participating centers. The trial is funded by the EU and a TKI PPP of Health Holland. In addition to the research, the Post Doc will be responsible for supervising PhDs, writing deliverable reports and scientific articles, writing grant applications and will be participating in national and international scientific meetings. We offer a pleasant and challenging learning environment. The Post Doc will have significant interaction with the other Post Docs and PhD students of our research group.
The Intensive Care department of the Academic Medical Center, Amsterdam (part of Amsterdam UMC) occupies a leading position internationally in its field of research and participate in a large number of cooperative programs with universities, research institutes and industry. One of the main research lines is the broad field of sepsis. The research group of the Department of Intensive Care and the Laboratory of Experimental Intensive Care and Anesthesiology exists of a multidisciplinary team with backgrounds in internal medicine, anesthesiology, intensive care medicine and biochemistry.
We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.
For an overview of all our other terms of employment, see https://werkenbijamc.nl/arbeidsvoorwaarden-amr/
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If you would like more information, please feel free to contact Alexander Vlaar (Principal Investigator), via firstname.lastname@example.org.
We look forward to meeting you!
Because of the coronavirus, healthcare is our main focus now in Amsterdam UMC. This means that it will probably take longer before we give you feedback on your application, or schedule job interviews. Thank you for your understanding!