Acute myeloid leukemia (AML) is a devastating disease with a high mortality. Patients often need the immunotherapeutic effect of an allogeneic hematopoietic stem cell transplantation (HCT) to be cured. We have demonstrated that AML patients who are cured after allogeneic HCT develop AML-specific antibody responses. Some of these antibodies with broad reactivity against AML cells of patients have the potential to be further developed into therapeutic antibodies. This research is performed at the Department of Hematology, Experimental Immunology and in close collaboration with the biotechnology company AIMM Therapeutics. We have an opportunity for a highly motivated and experienced scientist to strengthen our team. The candidate will be involved in the biochemical and functional characterization of novel therapeutic antibodies for treatment of AML. The candidate has a proven track-record in biochemistry and immunology and in the application of novel biochemical and molecular biology technologies for solving complex biological problems. He/she has a broad understanding of and experience with next generation sequencing, immune repertoire profiling and their applications.
A post-doctoral researcher with at least 4 years’ experience in molecular biology, biochemistry, in structural biology of macromolecular protein complexes, gene structures, cell biology or immunology. The candidate should have proven ability to independently perform scientific research, and develop and troubleshoot new experimental techniques and protocols. Education and Experience: Effective communication skills in English and the ability to successfully operate in a multifunctional team consisting of basic scientists and clinicians are essential.
This project is a collaboration between the research groups of Prof. dr. Mette Hazenberg from the department of Hematology, Prof. dr. Hergen Spits and dr. Bianca Blom from the department of Experimental Immunology at the Amsterdam UMC, location AMC. The laboratory of Experimental Immunology hosts around 70 PhD students and postdocs of various backgrounds (immunology, cell biology, biochemistry, virology). The department has a broad interest in fundamental immunological research ranging from tumorimmunology, allergy, HIV infection, rheumatology and asthma. Being close to the clinic we have strong collaborations with specialists and aim to translate our findings to patient care and design novel therapeutic interventions. For this project, which is funded by the Dutch Cancer Foundation, we have the ambition to develop previously identified antibodies reactive against AML cells of patients into therapeutic antibodies (Gillissen et al, Blood Adv. 2017;1(19):1551; Gillissen et al, Blood. 2018;131(1):131).
Want to know more about working at AMR? Take a look at our website https://werkenbijamc.nl/werken-bij-amr/.
We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.
For an overview of all our other terms of employment, see https://werkenbijamc.nl/arbeidsvoorwaarden-amr/
Amsterdam UMC has an open culture. Together we continuously build an environment where everyone feels welcome. To achieve that, we strive to provide equal opportunities for everyone. We therefore cordially invite all interested parties to respond to this vacancy.
If you would like to apply directly, please use the ‘apply’ button on this page.
If you would like more information, please feel free to contact [name] ([position]), via [tel. no.] or [e-mail]@amc.nl.
Please send your application in English together with CV and names of preferably three references (including email address and phone number) before 1 May 2021
We look forward to meeting you!