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Post-doctoral fellow on the ERC Consolidator project: Boosting T cells to enable CAR-T cell therapy for chronic lymphocytic leukemia

Apply before: 30 May 2020
Working time: Day
Working hours: 36 hours per week
Discipline: AMC Medical Research (AMR)
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What you are going to do

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. Novel targeted drugs such as Venetoclax and Ibrutinib are effective, but not curative. Moreover, prolonged use is associated with development of resistance, toxicity, and high economic cost. T cell-based approaches, e.g. chimeric antigen receptor T cells (CAR-T), are highly promising, however, in contrast to the success of CAR-T cells in aggressive leukemia, their effect in CLL is limited owing to a largely unexplained acquired T cell dysfunction in this disease setting. We recently found that CLL cells impose alterations in metabolic processes in T cells which may underlie the acquired T cell dysfunction. We therefore hypothesize that improving metabolic fitness of CAR-T cells may offer a path to cure CLL. To achieve this, we plan to conduct an array of complementary molecular, metabolic, and immunological modules using patient samples and a murine model of CLL. To address therapeutic potential we will study murine and human CAR-T cells in which (metabolic) processes will be manipulated. This study is supported by an ERC Consolidation grant. This position is perfectly suited for a passionate scientist aiming to work on an important biomedical problem, that combines aspects from the fields of high resolution (cancer) cell biology, immunology, metabolism, hematological malignancies, epigenetics and bioinformatics.

What we expect from you 

We are looking for PhD scientists at their first or second independent appointment to apply their expertise in a fully equipped high-level research laboratory close to a clinical setting. Required are scientific quality and originality, a successful track record of scientific achievements and profound expertise in at least one of the following particular research fields: metabolic studies, big-data-experimentation and -analysis, high level flow-cytometry and mouse experimentation.  Leadership skills, creativity, curiosity as well as a collaborative and interdisciplinary mindset are important ingredients to complete our research group.

Where you are going to work 

The Amsterdam University Medical Centers are academic hospitals that merge world-class basic and translational research with clinical care. Within the department of Experimental Immunology and Hematology, we are searching for an innovative, creative, ambitious scientist to become a Postdoctoral fellow  and to join our highly committed team of scientists and hematologists.

 

What we offer you

We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.

  • The maximum gross monthly salary based on a 36-hour work week is € 4.481,- (scale 10 CAO UMC). 
  • The base salary does not include holiday pay (8%) and a year-end bonus (8.3%). 
  • An initial 3-years employment contract with possible extension to 5 years leading towards tenure track. 
  • Full commitment to help you train, develop, submit grants (the institute has a very high success rate in obtaining prestigious (inter)national project and individual grants and awards). This includes support in the successful securement of additional funds and a possible tenure track of the institute.   
  • A package including a fully equipped laboratory, work on your own main project, and to participate in the different sub-projects of this grant, which can extend to full supervision of 1 PhD student and technical personnel and additional budget for consumables, facility services and travel expenses.
  • Full support, guidance and mentoring by professor Arnon Kater, clinical and translational hematologist and professor Eric Eldering, molecular immune- and cellular biologist.
  • A competitive salary and benefits package, including health and pension insurance. 
  • Access to administrative and scientific institutional support (HR, PR, grant service, etc.)  
  • In addition to excellent accessibility by public transport, AMC also has a sufficient number of parking spaces for employees.
  • Pension is accrued at Be Frank.

For an overview of all our other terms of employment, see https://werkenbijamc.nl/arbeidsvoorwaarden-amr/

Let’s meet

If you would like to apply directly, please use the ‘apply’ button on this page.
If you would like more information, please feel free to contact Arnon Kater (Professor of hematology), via a.p.kater@amsterdamumc.nl.

Applications should be written in English and contain:

  • Curriculum Vitae with full publication list
  • List of up to five most important papers with a short comment on why and what your contribution has been (each max. 80 words)
  • Funding track record or funding plans
  • Names and addresses of three references
  • Summary of research interests and objectives including how you could profit from and interact with our research team (max. 2 pages)

We look forward to meeting you!

Because of the coronavirus, healthcare is our main focus now in Amsterdam UMC. This means that it will probably take longer before we give you feedback on your application, or schedule job interviews. Thank you for your understanding!

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