Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. Novel targeted drugs such as Venetoclax and Ibrutinib are effective, but not curative. Moreover, prolonged use is associated with development of resistance, toxicity, and high economic cost. T cell-based approaches, e.g. chimeric antigen receptor T cells (CAR-T), are highly promising, however, in contrast to the success of CAR-T cells in aggressive leukemia, their effect in CLL is limited owing to a largely unexplained acquired T cell dysfunction in this disease setting. We recently found that CLL cells impose alterations in metabolic processes in T cells which may underlie the acquired T cell dysfunction. We therefore hypothesize that improving metabolic fitness of CAR-T cells may offer a path to cure CLL. To achieve this, we plan to conduct an array of complementary molecular, metabolic, and immunological modules using patient samples and a murine model of CLL. To address therapeutic potential we will study murine and human CAR-T cells in which (metabolic) processes will be manipulated. This study is supported by an ERC Consolidation grant. This position is perfectly suited for a passionate scientist aiming to work on an important biomedical problem, that combines aspects from the fields of high resolution (cancer) cell biology, immunology, metabolism, hematological malignancies, epigenetics and bioinformatics.
We are looking for PhD scientists at their first or second independent appointment to apply their expertise in a fully equipped high-level research laboratory close to a clinical setting. Required are scientific quality and originality, a successful track record of scientific achievements and profound expertise in at least one of the following particular research fields: metabolic studies, big-data-experimentation and -analysis, high level flow-cytometry and mouse experimentation. Leadership skills, creativity, curiosity as well as a collaborative and interdisciplinary mindset are important ingredients to complete our research group.
The Amsterdam University Medical Centers are academic hospitals that merge world-class basic and translational research with clinical care. Within the department of Experimental Immunology and Hematology, we are searching for an innovative, creative, ambitious scientist to become a Postdoctoral fellow and to join our highly committed team of scientists and hematologists.
We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.
For an overview of all our other terms of employment, see https://werkenbijamc.nl/arbeidsvoorwaarden-amr/
If you would like to apply directly, please use the ‘apply’ button on this page.
If you would like more information, please feel free to contact Arnon Kater (Professor of hematology), via firstname.lastname@example.org.
Applications should be written in English and contain:
We look forward to meeting you!
Because of the coronavirus, healthcare is our main focus now in Amsterdam UMC. This means that it will probably take longer before we give you feedback on your application, or schedule job interviews. Thank you for your understanding!